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KMID : 1146920230530020235
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Journal of Pharmaceutical Investigation
2023 Volume.53 No. 2 p.235 ~ p.248
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Formulation of secretome derived from mesenchymal stem cells for inflammatory skin diseases
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Seo Yoo-Jin
Tiep Tien Nguyen
Oh Su-Jeong
Jeong Jee-Heon
Kim Hyung-Sik
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Abstract
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Background : Growing evidence has demonstrated that the administration of mesenchymal stem cells (MSCs) in various inflammatory skin diseases caused by autoimmune or allergic reactions can be served as promising therapeutics owing to their immunomodulatory effect as well as tissue regenerative capacity.
Area covered : In this review, we summarize the therapeutic application of MSCs and their secretome targeting inflammatory skin diseases and current secretome engineering strategies for the clinical translation of cell-free therapeutics.
Expert opinion : Considering that direct application of MSCs often fails to reproduce stable therapeutic outcomes, partially due to harsh in vivo microenvironment leading to insufficient survival of injected cells, the concept of cell-free approaches utilizing MSC-derived paracrine factors including secretome and exosome has emerged to overcome present issues. Furthermore, various bioengineering techniques with biocompatible materials can be applied to modulate naive secretome to improve their delivery efficiency and bioavailability in vivo.
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KEYWORD
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Human mesenchymal stem cell, Canine mesenchymal stem cell, Stem cell therapy, Immunomodulation, Inflammatory skin disease, Secretome formulation
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